Barking and Dagenham College has been allocated £2.8 million for a range of improvement work, including new facilities for science, technology and environmental studies.
The cash, from the Skills Funding Agency, will also help pay for the refurbishment and modernisation of 1960s classrooms and the replacement of poor-quality workshops.
The college is one of more than 50 around the country to benefit from £412 million allocated to projects, subject to due diligence.
Business secretary Vince Cable said the tranche of funding would will transform the learning environment for thousands of students across the country.
"Addressing gaps in skills is an important part of our industrial strategy,” he said. “This initiative is another example of how government is working in long-term partnership with industry to give them more confidence to invest, hire and grow."
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